Honey, Natural Polymer to Produce Wound-Dressing Nanofibers:
A wide range of biological and biodegradable materials have been
electrospun in recent years to produce nanofibers. In this research, a
drug carrying nanofibrous web was produced to be used in wound dressing
by using an artificial and biodegradable polymer and a natural polymer
through electrospinning method.
Honey has antibacterial and anti-inflammation properties. Many studies
have been published on the effects of honey in the treatment of
infections and in prevention of the wound from being infected.
Therefore, the combination of the unique properties of nanofibers and
the natural properties of honey in the production of wound dressing is
the most important characteristic of this research.
SEM and AFM results showed that the fibers were completely homogenous
with relatively smooth surface. However, spindle-like beads were
observed in nanofibers containing 60% honey. As the concentration of
honey increased in the mixture, a decrease was observed in the diameter
of nanofibers. Drug-loaded nanofibers, too, had relatively smooth and
homogenous surface, and as the amount of drug increases, the diameter of
the nanofibers decreased. Drug release behavior studies demonstrated a
sudden initial release. Statistical analyses showed that the presence of
honey did not have significant effect on the process or on the behavior
of drug release. Therefore, electrospun nanofibers that contain honey
are appropriate option to be used in wound dressing.
Wounds can be dressed faster by using the achievements of this
research. Honey is considered as a well-known drug in traditional
medical sciences, which has been loaded with drugs in this research.
Results of the research have been published on 5 March 2013 in Journal
of Applied Polymer Science, vol. 127, issue 5, pp. 4086-4092
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